OBAT ANTI ARITMIA

Obat-obatan antiarrhythmic menurut Vaughan Williams dapat dibagi menjadi empat kelas (I-IV) didefinisikan berdasarkan efek electrophysiological pada miokardium. 
Obat class 1 : Sodium Channel Bloker  
1 A :(quinidine, procainamide dan dispopyramide), 1 B : lidocaine, mexiletine and tocainide , 1 C : flecainide, propafenone and moricizine
Obat calss 2 : Beta Adrenoceptor Blockers
Β1 Selective : Acebutolol, Atenolol, Bisoprolol, Esmolol (IV only), Metoprolol
Non (β 1) selective : Nadolol, Propranolol
Non Β selective and α receptor blockers : Carvedilol (used in heart failure management), Labetalol (IV form is used in acute hypertensive crisis)
Obat class 3 : Potassium Channel Blockers
Sotalol, Dofetilide, Ibutilide, Bretylium, Amiodarone
Obat class 4 : Calcium channel blockers
Dihydropyridine; vasodilators selektif bekerja pada otot polos perifer
Amlodipine, Felodipine, Isradipine, Nicardipine, Nifedipine
Benzothiazepine; less selective vasodilator activity, depresses sinus node and AV node
DIltiazem
Phenylalkylamine; less selective vasodilator activity, depresses sinus node and AV node
Verapamil

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